Research Overview

Natural products are a rich source of pharmaceutical drug leads. Inspired by the application(s) of secondary metabolites in human disease, research in the Frederich laboratory focuses on developing new strategies and methods to prepare architecturally complex molecules that exhibit important biological activity in living systems. A critical aspect of this endeavor involves designing new reactions that build molecular complexity, thereby allowing us to approach challenging structures in a practical way. Access to targeted natural products and designed synthetic variants will open exciting avenues to explore their pharmacology. Complementary exercises in molecular biology, biophysics and biochemistry will then become part of interdisciplinary and collaborative research aimed at translating discoveries in complex molecule synthesis to new therapies for human disease.

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