The Frederich Laboratory
Complex Molecule Synthesis & Molecular Pharmacology
Peer-Reviewed Publicaitons
22. Enantioselective total synthesis of (+)-fusicoccadiene via photocatalytic polyene isomerization
VS Basistyi, TD Weinhold, JA Pinkerton, JA Law, and JH Frederich*
J. Am. Chem. Soc. 2026, 148, 124–129.
21. Direct ketone cyclopropanation enabled by Tebbe's reagent
TD Weinhold, JC Vins, and JH Frederich*
Tetrahedron Lett. 2026, 178, 156002.
SN Duong, KA Barnes,* and JH Frederich*
Rejuv. Res. 2026, 29, 193–210.
19. Taxodione inhibits glioblastoma proliferation and potentiates the cytotoxicity of paclitaxel
K Parella, MM Solans, C Vied, H Colegrove, S Kononenko, DAR Zorio, VS Basistyi, and JH Frederich*
ACS Chem. Biol. 2025, 20, 2368–2374.
A Piwko, MA Jeffes, JH Frederich,* and BG Miller*
ACS Chem. Biol. 2025, 20, 2779–2786.
17. Access to 3-azetidines via halogenation of titanacyclobutanes
TD Weinhold, JA Law, and JH Frederich*
Adv. Synth. Catal. 2024, 366, 2214–2219.
15. A sticky situation for targeted cancer therapy
VS Basistyi and JH Frederich*
Cell Chem. Biol. 2023, 30, 569–572.
14. A stereoselective photoinduced cycloisomerization inspired by ophiobolin A
JA Law, DP Callen, EL Paola, G Gomes* and JH Frederich*
Org. Lett, 2022, 24, 6499–6504.
Preprint: 10.26434/chemrxiv-2022-wjsd9
13. Programmed polyene cyclization enabled by chromophore disruption
MM Solans, VS Basistyi, JA Law, NM Bartfield and JH Frederich*
J. Am. Chem. Soc. 2022, 144, 6193–6199. DOI: 10.1021/jacs/2c02144
Preprint: 10.26434/chemrxiv-2022-npd5r-v2
12. Pyridazine N-oxides as photoactivatable surrogates for reactive oxygen species
VS Basistyi and JH Frederich*
Org. Lett. 2022, 24, 1907–1912. DOI: 10.1021/acs.orglett.2c00227
11. Site-specific alkene hydromethylation via protonolysis of titanacyclobutanes
JA Law, NM Bartfield, and JH Frederich*
Angew. Chem., Int. Ed. 2021, 60, 14360–14364. DOI: 10.1002/anie.202103278
9. Analysis of interactions stabilized by fusicoccin A reveals an expanded suite of potential 14-3-3 binding partners
A Sengupta, J Liriano, BG Miller and JH Frederich*
ACS Chem. Bio. 2020, 15, 305–310. DOI: 10.1021/acschembio.9b00795
8. A photoinduced cascade for the synthesis of 1H-indole-2-acetamide derivatives
M Borger, DP Callen and JH Frederich*
Asian J. Org. Chem. 2019, 8, 1111–1114. DOI: 10.1002/ajoc.201900201
Special Issue – Advances in Heterocyclic Chemistry
A Sengupta, J Liriano, EA Bienkiewicz, BG Miller and JH Frederich*
ACS Omega 2020, 5, 25029–25035. DOI: 10.1021/acsomega.0c01454
M Borger and JH Frederich*
Org. Lett. 2019, 21, 2397–2401. DOI: 10.1021/acs.orglett.9b00682
AE Salvati, JA Law, J Liriano and JH Frederich*
Chem. Sci. 2018, 9, 5389–5393. DOI: 10.1039/c8sc00999f
This work was highlighted in Chemistry World
5. Synthesis of nitrogen heterocycles via photochemical ring opening of pyridazine N-oxides
M Portillo, MA Maxwell and JH Frederich*
Org. Lett. 2016, 18, 5142–5145. DOI: 10.1021/acs.orglett.6b02562.
Prior to independent career
4. Tailored fragments of roseophilin selectively antagonize Mcl-1 in vitro
JD Bracken, AD Carlson, JH Frederich, M Nguyen, GS Shore and PG Harran*
Tetrahedron Lett. 2015, 56, 3612–3616.
Memorial Symposium-in-Print for Harry Wasserman
3. Modular access to complex prodiginines: Total synthesis of (+)-roseophilin via its 2-azafulvene prototropisomer
JH Frederich and PG Harran*
J. Am. Chem. Soc. 2013, 135, 3788–3791.
2. Substituted 2,2'-bipyrroles and pyrrolylfurans via intermediate isoxazolylpyrroles
JH Frederich, JK Matsui, RO Chang, and PG Harran*
Tetrahedron Lett. 2013, 54, 2645–2647.
1. Palladacyclic imidazoline-naphthalene complexes: Synthesis and catalytic performance in Pd(II)-catalyzed enantioselective reactions of allylic trichloroacetimidates
JS Cannon, JH Frederich and LE Overman*
J. Org. Chem. 2012, 77, 1939–1951.