Natural products provide a rich source of pharmaceutical drug leads. Inspired by the application(s) of secondary metabolites in understanding and treating human disease, research in the Frederich Lab focuses on developing strategies and tactics to prepare architecturally complex natural products that exhibit important biological activity in living systems. A critical aspect of this endeavor involves the design of new reactions that build molecular complexity, thereby allowing us to approach challenging structures in a practical way. We are also deeply committed to understanding the pharmacology of targets under investigation in our lab. As such, exercises in molecular biology, biophysics and medicinal chemistry are aspects of long-term interdisciplinary research aimed at identifying new drug targets and developing prototype therapeutics.